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KMID : 0361019940370040753
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Korean Journal of Otolaryngology - Head and Neck Surgery
1994 Volume.37 No. 4 p.753 ~ p.759
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Immunohistochemical Study on the Expression of p53 Protein in Adenoid Cystic Carcinoma of the Head and Neck
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김광현
성명훈/장근호/이재서/조양선
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Abstract
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Overexpression of the mutant p53, derived from mutation of the p53 gene which is located on the short arm of chromosome 17 and plays a role in suppresion of the tumor, has been reported in some human malignancy such as breast or colon cancer and
suggested to be a prognostic factor.
The authors investigated expression of p53 protein by immunohistochemical staining using anti-p53 monoclonal antibody in the paraffin embedded blocks of the 23 patients who were diagnosed as adenoid cystic carcinoma of the head and neck between
1979 and
1991, and could be followed-up.
Seven (30%) out of the 23 cases showed p53 expression, and there was no significant association between p53 positivity and local recurrence (p=0.41) or distant metastasis (p=0.18).
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KEYWORD
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